Misamfu Regional Research Centre is found in Kasama, Northern Province and is one of the research stations in the country. It is under the Ministry of Agriculture, under the Zambia Agriculture Research Institute (ZARI). It is the coordinating center for region III (high rainfall zone above 1000 mm per annum), comprising four provinces namely; Northern, Luapula, Copperbelt and North-Western and Muchinga Provinces with Misamfu Regional Research Centre, Mansa Technological Assessment Site, Mufulira Technological Assessment, Mutanda Research Station, respectively. Misamfu was elevated to a Regional Research Centre in 1991.
The name Misamfu is derived from the stream that cuts the research land almost in half. Offices and residential homes are found on the western side of the stream.
During the federation of Rhodesia and Nyasaland in 1957, the experimental research station was earlier located in Mbala district at Lunzuwa (1940s), it was not until 1957 that it was transferred to Kasama at the Misamfu. The first work to be conducted was on station was on tobacco experiments. By 1980 Soil Survey had started with support. In early eighties, permanent research programmes were established at Misamfu , these are Soil Productivity Research Programme (SPRP) in 1981, Rain fed Wheat Research in 1983, Coffee Project in 1984, Farming Systems Research (Adaptive Farming Systems Team, then) in 1985, and Sorghum and Millet Improvement Programme in 1989. Since then the programmes have increased to include Food Legumes, Rice, and Roots and Tuber Crops. At the end of 1998 Plant Protection Team was established comprising two sections, Entomology and Pathology. In early 1999 a Seed Quality Control Unit was established, making the Centre offer almost all basic agricultural needs in the Region.